Rationale, design, and progress of the ENhanced Control of Hypertension ANd Thrombolysis strokE stuDy (ENCHANTED) trial: An international multicenter 2 × 2 quasi-factorial randomized controlled trial of low- vs. standard-dose rt-PA and early intensive vs. guideline-recommended blood pressure lowering in patients with acute ischaemic stroke eligible for thrombolysis treatment.
Identifieur interne : 002918 ( Main/Exploration ); précédent : 002917; suivant : 002919Rationale, design, and progress of the ENhanced Control of Hypertension ANd Thrombolysis strokE stuDy (ENCHANTED) trial: An international multicenter 2 × 2 quasi-factorial randomized controlled trial of low- vs. standard-dose rt-PA and early intensive vs. guideline-recommended blood pressure lowering in patients with acute ischaemic stroke eligible for thrombolysis treatment.
Auteurs : Yining Huang [République populaire de Chine] ; Vijay K. Sharma [Singapour] ; Thompson Robinson [Royaume-Uni] ; Richard I. Lindley [Australie] ; Xiaoying Chen [Australie] ; Jong Sung Kim [Corée du Sud] ; Pablo Lavados [Chili] ; Ver Nica Olavarría [Chili] ; Hisatomi Arima [Australie] ; Sully Fuentes [Australie] ; Huy Thang Nguyen [Viêt Nam] ; Tsong-Hai Lee [Taïwan] ; Mark W. Parsons [Australie] ; Christopher Levi [Australie] ; Andrew M. Demchuk [Canada] ; Philip M W. Bath [Royaume-Uni] ; Joseph P. Broderick [États-Unis] ; Geoffrey A. Donnan [Australie] ; Sheila Martins [Brésil] ; Octavio M. Pontes-Neto [Brésil] ; Federico Silva [Colombie] ; Jeyaraj Pandian [Inde] ; Stefano Ricci [Italie] ; Christian Stapf [France] ; Mark Woodward [Australie] ; Jiguang Wang [République populaire de Chine] ; John Chalmers [Australie] ; Craig S. Anderson [Australie]Source :
- International journal of stroke : official journal of the International Stroke Society [ 1747-4949 ] ; 2015.
Descripteurs français
- KwdFr :
- Accident vasculaire cérébral (traitement médicamenteux), Accident vasculaire cérébral (étiologie), Activateur tissulaire du plasminogène (usage thérapeutique), Coopération internationale, Encéphalopathie ischémique (), Femelle, Fibrinolytiques (usage thérapeutique), Humains, Mâle, Résultat thérapeutique.
- MESH :
- traitement médicamenteux : Accident vasculaire cérébral.
- usage thérapeutique : Activateur tissulaire du plasminogène, Fibrinolytiques.
- étiologie : Accident vasculaire cérébral.
- Coopération internationale, Encéphalopathie ischémique, Femelle, Humains, Mâle, Résultat thérapeutique.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Fibrinolytic Agents, Tissue Plasminogen Activator.
- complications : Brain Ischemia.
- drug therapy : Stroke.
- etiology : Stroke.
- Female, Humans, International Cooperation, Male, Treatment Outcome.
Abstract
Controversy exists over the optimal dose of intravenous (i.v.) recombinant tissue plasminogen activator (rt-PA) and degree of blood pressure (BP) control in acute ischaemic stroke (AIS). Asian studies suggest low-dose (0·6 mg/kg) is more efficacious than standard-dose (0·9 mg/kg) i.v. rt-PA, and guidelines recommend reducing systolic BP to <185 mmHg before and <180 mmHg after use of i.v. rt-PA, despite observational studies indicating better outcomes at much lower (<140 mmHg) systolic BP levels in this patient group.
DOI: 10.1111/ijs.12486
PubMed: 25832995
Affiliations:
- Australie, Brésil, Canada, Chili, Colombie, Corée du Sud, France, Inde, Italie, Royaume-Uni, République populaire de Chine, Singapour, Taïwan, Viêt Nam, États-Unis
- Alberta, Angleterre, Nottinghamshire, Nouvelle-Galles du Sud, Ohio, Rio Grande do Sul, Région capitale de Séoul, État de São Paulo, Île-de-France
- Calgary, Nottingham, Paris, Porto Alegre, Pékin, Sydney, São Paulo, Séoul
- Université de Calgary, Université de Nottingham, Université de Sydney, Université de São Paulo, Université fédérale du Rio Grande do Sul, Université nationale de Singapour
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Le document en format XML
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Sharma</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neurology, Department of Medicine, National University Hospital and YLL School of Medicine, National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Division of Neurology, Department of Medicine, National University Hospital and YLL School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Robinson, Thompson" sort="Robinson, Thompson" uniqKey="Robinson T" first="Thompson" last="Robinson">Thompson Robinson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences and NIHR Biomedical Research Unit, University of Leicester University, Leicester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Sciences and NIHR Biomedical Research Unit, University of Leicester University, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Lindley, Richard I" sort="Lindley, Richard I" uniqKey="Lindley R" first="Richard I" last="Lindley">Richard I. Lindley</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Chen, Xiaoying" sort="Chen, Xiaoying" uniqKey="Chen X" first="Xiaoying" last="Chen">Xiaoying Chen</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Kim, Jong Sung" sort="Kim, Jong Sung" uniqKey="Kim J" first="Jong Sung" last="Kim">Jong Sung Kim</name><affiliation wicri:level="3"><nlm:affiliation>Asan Medical Center, University of Ulsan, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Asan Medical Center, University of Ulsan, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lavados, Pablo" sort="Lavados, Pablo" uniqKey="Lavados P" first="Pablo" last="Lavados">Pablo Lavados</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Alemana de Santiago, Universidad del Desarrollo, Santiago, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Clinica Alemana de Santiago, Universidad del Desarrollo, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Olavarria, Ver Nica" sort="Olavarria, Ver Nica" uniqKey="Olavarria V" first="Ver Nica" last="Olavarría">Ver Nica Olavarría</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Alemana de Santiago, Universidad del Desarrollo, Santiago, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Clinica Alemana de Santiago, Universidad del Desarrollo, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Arima, Hisatomi" sort="Arima, Hisatomi" uniqKey="Arima H" first="Hisatomi" last="Arima">Hisatomi Arima</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Fuentes, Sully" sort="Fuentes, Sully" uniqKey="Fuentes S" first="Sully" last="Fuentes">Sully Fuentes</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Nguyen, Huy Thang" sort="Nguyen, Huy Thang" uniqKey="Nguyen H" first="Huy Thang" last="Nguyen">Huy Thang Nguyen</name><affiliation wicri:level="1"><nlm:affiliation>Stroke Unit, People's 115 Hospital, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Stroke Unit, People's 115 Hospital, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Tsong Hai" sort="Lee, Tsong Hai" uniqKey="Lee T" first="Tsong-Hai" last="Lee">Tsong-Hai Lee</name><affiliation wicri:level="1"><nlm:affiliation>Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Linkou Chang Gung Memorial Hospital, Taoyuan</wicri:regionArea><wicri:noRegion>Taoyuan</wicri:noRegion></affiliation></author><author><name sortKey="Parsons, Mark W" sort="Parsons, Mark W" uniqKey="Parsons M" first="Mark W" last="Parsons">Mark W. Parsons</name><affiliation wicri:level="1"><nlm:affiliation>John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, Newcastle</wicri:regionArea><wicri:noRegion>Newcastle</wicri:noRegion></affiliation></author><author><name sortKey="Levi, Christopher" sort="Levi, Christopher" uniqKey="Levi C" first="Christopher" last="Levi">Christopher Levi</name><affiliation wicri:level="1"><nlm:affiliation>John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, Newcastle</wicri:regionArea><wicri:noRegion>Newcastle</wicri:noRegion></affiliation></author><author><name sortKey="Demchuk, Andrew M" sort="Demchuk, Andrew M" uniqKey="Demchuk A" first="Andrew M" last="Demchuk">Andrew M. Demchuk</name><affiliation wicri:level="4"><nlm:affiliation>Calgary Stroke Program, Department of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Calgary Stroke Program, Department of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Bath, Philip M W" sort="Bath, Philip M W" uniqKey="Bath P" first="Philip M W" last="Bath">Philip M W. Bath</name><affiliation wicri:level="4"><nlm:affiliation>Stroke trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Broderick, Joseph P" sort="Broderick, Joseph P" uniqKey="Broderick J" first="Joseph P" last="Broderick">Joseph P. Broderick</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Donnan, Geoffrey A" sort="Donnan, Geoffrey A" uniqKey="Donnan G" first="Geoffrey A" last="Donnan">Geoffrey A. Donnan</name><affiliation wicri:level="1"><nlm:affiliation>The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Martins, Sheila" sort="Martins, Sheila" uniqKey="Martins S" first="Sheila" last="Martins">Sheila Martins</name><affiliation wicri:level="4"><nlm:affiliation>Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio grande do Sul, Rio Grande do Sul, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio grande do Sul, Rio Grande do Sul</wicri:regionArea><placeName><region type="state">Rio Grande do Sul</region><settlement type="city">Porto Alegre</settlement></placeName><orgName type="university">Université fédérale du Rio Grande do Sul</orgName></affiliation></author><author><name sortKey="Pontes Neto, Octavio M" sort="Pontes Neto, Octavio M" uniqKey="Pontes Neto O" first="Octavio M" last="Pontes-Neto">Octavio M. Pontes-Neto</name><affiliation wicri:level="4"><nlm:affiliation>Stroke Service - Neurology Division, Department of Neuroscience and Behavior, Ribeirão Preto School of Medicine, University of Sao Paulo, Ribeirão Preto, SP, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Stroke Service - Neurology Division, Department of Neuroscience and Behavior, Ribeirão Preto School of Medicine, University of Sao Paulo, Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Silva, Federico" sort="Silva, Federico" uniqKey="Silva F" first="Federico" last="Silva">Federico Silva</name><affiliation wicri:level="1"><nlm:affiliation>Fundación Cardiovascular, Bucaramanga, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Fundación Cardiovascular, Bucaramanga</wicri:regionArea><wicri:noRegion>Bucaramanga</wicri:noRegion></affiliation></author><author><name sortKey="Pandian, Jeyaraj" sort="Pandian, Jeyaraj" uniqKey="Pandian J" first="Jeyaraj" last="Pandian">Jeyaraj Pandian</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Christian Medical College, Ludhiana, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Neurology, Christian Medical College, Ludhiana</wicri:regionArea><wicri:noRegion>Ludhiana</wicri:noRegion></affiliation></author><author><name sortKey="Ricci, Stefano" sort="Ricci, Stefano" uniqKey="Ricci S" first="Stefano" last="Ricci">Stefano Ricci</name><affiliation wicri:level="1"><nlm:affiliation>Direttore, UO Neurologia, USL Umbria 1, Sedi di Città di Castello e Branca, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Direttore, UO Neurologia, USL Umbria 1, Sedi di Città di Castello e Branca</wicri:regionArea><wicri:noRegion>Sedi di Città di Castello e Branca</wicri:noRegion></affiliation></author><author><name sortKey="Stapf, Christian" sort="Stapf, Christian" uniqKey="Stapf C" first="Christian" last="Stapf">Christian Stapf</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, APHP - Hôpital Lariboisière and DHU NeuroVasc Paris - Sorbonne, Univ Paris Diderot - Sorbonne Paris Cité, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, APHP - Hôpital Lariboisière and DHU NeuroVasc Paris - Sorbonne, Univ Paris Diderot - Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Wang, Jiguang" sort="Wang, Jiguang" uniqKey="Wang J" first="Jiguang" last="Wang">Jiguang Wang</name><affiliation wicri:level="1"><nlm:affiliation>The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Anderson, Craig S" sort="Anderson, Craig S" uniqKey="Anderson C" first="Craig S" last="Anderson">Craig S. Anderson</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25832995</idno><idno type="pmid">25832995</idno><idno type="doi">10.1111/ijs.12486</idno><idno type="wicri:Area/PubMed/Corpus">002C28</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002C28</idno><idno type="wicri:Area/PubMed/Curation">002B55</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002B55</idno><idno type="wicri:Area/PubMed/Checkpoint">002B55</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002B55</idno><idno type="wicri:Area/Ncbi/Merge">002409</idno><idno type="wicri:Area/Ncbi/Curation">002409</idno><idno type="wicri:Area/Ncbi/Checkpoint">002409</idno><idno type="wicri:Area/Main/Merge">002918</idno><idno type="wicri:Area/Main/Curation">002918</idno><idno type="wicri:Area/Main/Exploration">002918</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Rationale, design, and progress of the ENhanced Control of Hypertension ANd Thrombolysis strokE stuDy (ENCHANTED) trial: An international multicenter 2 × 2 quasi-factorial randomized controlled trial of low- vs. standard-dose rt-PA and early intensive vs. guideline-recommended blood pressure lowering in patients with acute ischaemic stroke eligible for thrombolysis treatment.</title><author><name sortKey="Huang, Yining" sort="Huang, Yining" uniqKey="Huang Y" first="Yining" last="Huang">Yining Huang</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Peking University First Hospital, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology, Peking University First Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Sharma, Vijay K" sort="Sharma, Vijay K" uniqKey="Sharma V" first="Vijay K" last="Sharma">Vijay K. Sharma</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neurology, Department of Medicine, National University Hospital and YLL School of Medicine, National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Division of Neurology, Department of Medicine, National University Hospital and YLL School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Robinson, Thompson" sort="Robinson, Thompson" uniqKey="Robinson T" first="Thompson" last="Robinson">Thompson Robinson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences and NIHR Biomedical Research Unit, University of Leicester University, Leicester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Sciences and NIHR Biomedical Research Unit, University of Leicester University, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Lindley, Richard I" sort="Lindley, Richard I" uniqKey="Lindley R" first="Richard I" last="Lindley">Richard I. Lindley</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Chen, Xiaoying" sort="Chen, Xiaoying" uniqKey="Chen X" first="Xiaoying" last="Chen">Xiaoying Chen</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Kim, Jong Sung" sort="Kim, Jong Sung" uniqKey="Kim J" first="Jong Sung" last="Kim">Jong Sung Kim</name><affiliation wicri:level="3"><nlm:affiliation>Asan Medical Center, University of Ulsan, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Asan Medical Center, University of Ulsan, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lavados, Pablo" sort="Lavados, Pablo" uniqKey="Lavados P" first="Pablo" last="Lavados">Pablo Lavados</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Alemana de Santiago, Universidad del Desarrollo, Santiago, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Clinica Alemana de Santiago, Universidad del Desarrollo, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Olavarria, Ver Nica" sort="Olavarria, Ver Nica" uniqKey="Olavarria V" first="Ver Nica" last="Olavarría">Ver Nica Olavarría</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Alemana de Santiago, Universidad del Desarrollo, Santiago, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Clinica Alemana de Santiago, Universidad del Desarrollo, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Arima, Hisatomi" sort="Arima, Hisatomi" uniqKey="Arima H" first="Hisatomi" last="Arima">Hisatomi Arima</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Fuentes, Sully" sort="Fuentes, Sully" uniqKey="Fuentes S" first="Sully" last="Fuentes">Sully Fuentes</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Nguyen, Huy Thang" sort="Nguyen, Huy Thang" uniqKey="Nguyen H" first="Huy Thang" last="Nguyen">Huy Thang Nguyen</name><affiliation wicri:level="1"><nlm:affiliation>Stroke Unit, People's 115 Hospital, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Stroke Unit, People's 115 Hospital, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Tsong Hai" sort="Lee, Tsong Hai" uniqKey="Lee T" first="Tsong-Hai" last="Lee">Tsong-Hai Lee</name><affiliation wicri:level="1"><nlm:affiliation>Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Linkou Chang Gung Memorial Hospital, Taoyuan</wicri:regionArea><wicri:noRegion>Taoyuan</wicri:noRegion></affiliation></author><author><name sortKey="Parsons, Mark W" sort="Parsons, Mark W" uniqKey="Parsons M" first="Mark W" last="Parsons">Mark W. Parsons</name><affiliation wicri:level="1"><nlm:affiliation>John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, Newcastle</wicri:regionArea><wicri:noRegion>Newcastle</wicri:noRegion></affiliation></author><author><name sortKey="Levi, Christopher" sort="Levi, Christopher" uniqKey="Levi C" first="Christopher" last="Levi">Christopher Levi</name><affiliation wicri:level="1"><nlm:affiliation>John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, Newcastle</wicri:regionArea><wicri:noRegion>Newcastle</wicri:noRegion></affiliation></author><author><name sortKey="Demchuk, Andrew M" sort="Demchuk, Andrew M" uniqKey="Demchuk A" first="Andrew M" last="Demchuk">Andrew M. Demchuk</name><affiliation wicri:level="4"><nlm:affiliation>Calgary Stroke Program, Department of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Calgary Stroke Program, Department of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Bath, Philip M W" sort="Bath, Philip M W" uniqKey="Bath P" first="Philip M W" last="Bath">Philip M W. Bath</name><affiliation wicri:level="4"><nlm:affiliation>Stroke trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Broderick, Joseph P" sort="Broderick, Joseph P" uniqKey="Broderick J" first="Joseph P" last="Broderick">Joseph P. Broderick</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Donnan, Geoffrey A" sort="Donnan, Geoffrey A" uniqKey="Donnan G" first="Geoffrey A" last="Donnan">Geoffrey A. Donnan</name><affiliation wicri:level="1"><nlm:affiliation>The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Martins, Sheila" sort="Martins, Sheila" uniqKey="Martins S" first="Sheila" last="Martins">Sheila Martins</name><affiliation wicri:level="4"><nlm:affiliation>Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio grande do Sul, Rio Grande do Sul, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio grande do Sul, Rio Grande do Sul</wicri:regionArea><placeName><region type="state">Rio Grande do Sul</region><settlement type="city">Porto Alegre</settlement></placeName><orgName type="university">Université fédérale du Rio Grande do Sul</orgName></affiliation></author><author><name sortKey="Pontes Neto, Octavio M" sort="Pontes Neto, Octavio M" uniqKey="Pontes Neto O" first="Octavio M" last="Pontes-Neto">Octavio M. Pontes-Neto</name><affiliation wicri:level="4"><nlm:affiliation>Stroke Service - Neurology Division, Department of Neuroscience and Behavior, Ribeirão Preto School of Medicine, University of Sao Paulo, Ribeirão Preto, SP, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Stroke Service - Neurology Division, Department of Neuroscience and Behavior, Ribeirão Preto School of Medicine, University of Sao Paulo, Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Silva, Federico" sort="Silva, Federico" uniqKey="Silva F" first="Federico" last="Silva">Federico Silva</name><affiliation wicri:level="1"><nlm:affiliation>Fundación Cardiovascular, Bucaramanga, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Fundación Cardiovascular, Bucaramanga</wicri:regionArea><wicri:noRegion>Bucaramanga</wicri:noRegion></affiliation></author><author><name sortKey="Pandian, Jeyaraj" sort="Pandian, Jeyaraj" uniqKey="Pandian J" first="Jeyaraj" last="Pandian">Jeyaraj Pandian</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Christian Medical College, Ludhiana, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Neurology, Christian Medical College, Ludhiana</wicri:regionArea><wicri:noRegion>Ludhiana</wicri:noRegion></affiliation></author><author><name sortKey="Ricci, Stefano" sort="Ricci, Stefano" uniqKey="Ricci S" first="Stefano" last="Ricci">Stefano Ricci</name><affiliation wicri:level="1"><nlm:affiliation>Direttore, UO Neurologia, USL Umbria 1, Sedi di Città di Castello e Branca, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Direttore, UO Neurologia, USL Umbria 1, Sedi di Città di Castello e Branca</wicri:regionArea><wicri:noRegion>Sedi di Città di Castello e Branca</wicri:noRegion></affiliation></author><author><name sortKey="Stapf, Christian" sort="Stapf, Christian" uniqKey="Stapf C" first="Christian" last="Stapf">Christian Stapf</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, APHP - Hôpital Lariboisière and DHU NeuroVasc Paris - Sorbonne, Univ Paris Diderot - Sorbonne Paris Cité, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, APHP - Hôpital Lariboisière and DHU NeuroVasc Paris - Sorbonne, Univ Paris Diderot - Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Wang, Jiguang" sort="Wang, Jiguang" uniqKey="Wang J" first="Jiguang" last="Wang">Jiguang Wang</name><affiliation wicri:level="1"><nlm:affiliation>The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Anderson, Craig S" sort="Anderson, Craig S" uniqKey="Anderson C" first="Craig S" last="Anderson">Craig S. Anderson</name><affiliation wicri:level="4"><nlm:affiliation>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author></analytic><series><title level="j">International journal of stroke : official journal of the International Stroke Society</title><idno type="eISSN">1747-4949</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain Ischemia (complications)</term><term>Female</term><term>Fibrinolytic Agents (therapeutic use)</term><term>Humans</term><term>International Cooperation</term><term>Male</term><term>Stroke (drug therapy)</term><term>Stroke (etiology)</term><term>Tissue Plasminogen Activator (therapeutic use)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral (traitement médicamenteux)</term><term>Accident vasculaire cérébral (étiologie)</term><term>Activateur tissulaire du plasminogène (usage thérapeutique)</term><term>Coopération internationale</term><term>Encéphalopathie ischémique ()</term><term>Femelle</term><term>Fibrinolytiques (usage thérapeutique)</term><term>Humains</term><term>Mâle</term><term>Résultat thérapeutique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Fibrinolytic Agents</term><term>Tissue Plasminogen Activator</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Brain Ischemia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Accident vasculaire cérébral</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Activateur tissulaire du plasminogène</term><term>Fibrinolytiques</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Accident vasculaire cérébral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>International Cooperation</term><term>Male</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Coopération internationale</term><term>Encéphalopathie ischémique</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Résultat thérapeutique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Controversy exists over the optimal dose of intravenous (i.v.) recombinant tissue plasminogen activator (rt-PA) and degree of blood pressure (BP) control in acute ischaemic stroke (AIS). Asian studies suggest low-dose (0·6 mg/kg) is more efficacious than standard-dose (0·9 mg/kg) i.v. rt-PA, and guidelines recommend reducing systolic BP to <185 mmHg before and <180 mmHg after use of i.v. rt-PA, despite observational studies indicating better outcomes at much lower (<140 mmHg) systolic BP levels in this patient group.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Brésil</li><li>Canada</li><li>Chili</li><li>Colombie</li><li>Corée du Sud</li><li>France</li><li>Inde</li><li>Italie</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>Singapour</li><li>Taïwan</li><li>Viêt Nam</li><li>États-Unis</li></country><region><li>Alberta</li><li>Angleterre</li><li>Nottinghamshire</li><li>Nouvelle-Galles du Sud</li><li>Ohio</li><li>Rio Grande do Sul</li><li>Région capitale de Séoul</li><li>État de São Paulo</li><li>Île-de-France</li></region><settlement><li>Calgary</li><li>Nottingham</li><li>Paris</li><li>Porto Alegre</li><li>Pékin</li><li>Sydney</li><li>São Paulo</li><li>Séoul</li></settlement><orgName><li>Université de Calgary</li><li>Université de Nottingham</li><li>Université de Sydney</li><li>Université de São Paulo</li><li>Université fédérale du Rio Grande do Sul</li><li>Université nationale de Singapour</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Huang, Yining" sort="Huang, Yining" uniqKey="Huang Y" first="Yining" last="Huang">Yining Huang</name></noRegion><name sortKey="Wang, Jiguang" sort="Wang, Jiguang" uniqKey="Wang J" first="Jiguang" last="Wang">Jiguang Wang</name></country><country name="Singapour"><noRegion><name sortKey="Sharma, Vijay K" sort="Sharma, Vijay K" uniqKey="Sharma V" first="Vijay K" last="Sharma">Vijay K. Sharma</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Robinson, Thompson" sort="Robinson, Thompson" uniqKey="Robinson T" first="Thompson" last="Robinson">Thompson Robinson</name></noRegion><name sortKey="Bath, Philip M W" sort="Bath, Philip M W" uniqKey="Bath P" first="Philip M W" last="Bath">Philip M W. Bath</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Lindley, Richard I" sort="Lindley, Richard I" uniqKey="Lindley R" first="Richard I" last="Lindley">Richard I. Lindley</name></region><name sortKey="Anderson, Craig S" sort="Anderson, Craig S" uniqKey="Anderson C" first="Craig S" last="Anderson">Craig S. Anderson</name><name sortKey="Arima, Hisatomi" sort="Arima, Hisatomi" uniqKey="Arima H" first="Hisatomi" last="Arima">Hisatomi Arima</name><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><name sortKey="Chen, Xiaoying" sort="Chen, Xiaoying" uniqKey="Chen X" first="Xiaoying" last="Chen">Xiaoying Chen</name><name sortKey="Donnan, Geoffrey A" sort="Donnan, Geoffrey A" uniqKey="Donnan G" first="Geoffrey A" last="Donnan">Geoffrey A. Donnan</name><name sortKey="Fuentes, Sully" sort="Fuentes, Sully" uniqKey="Fuentes S" first="Sully" last="Fuentes">Sully Fuentes</name><name sortKey="Levi, Christopher" sort="Levi, Christopher" uniqKey="Levi C" first="Christopher" last="Levi">Christopher Levi</name><name sortKey="Parsons, Mark W" sort="Parsons, Mark W" uniqKey="Parsons M" first="Mark W" last="Parsons">Mark W. Parsons</name><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kim, Jong Sung" sort="Kim, Jong Sung" uniqKey="Kim J" first="Jong Sung" last="Kim">Jong Sung Kim</name></region></country><country name="Chili"><noRegion><name sortKey="Lavados, Pablo" sort="Lavados, Pablo" uniqKey="Lavados P" first="Pablo" last="Lavados">Pablo Lavados</name></noRegion><name sortKey="Olavarria, Ver Nica" sort="Olavarria, Ver Nica" uniqKey="Olavarria V" first="Ver Nica" last="Olavarría">Ver Nica Olavarría</name></country><country name="Viêt Nam"><noRegion><name sortKey="Nguyen, Huy Thang" sort="Nguyen, Huy Thang" uniqKey="Nguyen H" first="Huy Thang" last="Nguyen">Huy Thang Nguyen</name></noRegion></country><country name="Taïwan"><noRegion><name sortKey="Lee, Tsong Hai" sort="Lee, Tsong Hai" uniqKey="Lee T" first="Tsong-Hai" last="Lee">Tsong-Hai Lee</name></noRegion></country><country name="Canada"><region name="Alberta"><name sortKey="Demchuk, Andrew M" sort="Demchuk, Andrew M" uniqKey="Demchuk A" first="Andrew M" last="Demchuk">Andrew M. Demchuk</name></region></country><country name="États-Unis"><region name="Ohio"><name sortKey="Broderick, Joseph P" sort="Broderick, Joseph P" uniqKey="Broderick J" first="Joseph P" last="Broderick">Joseph P. Broderick</name></region></country><country name="Brésil"><region name="Rio Grande do Sul"><name sortKey="Martins, Sheila" sort="Martins, Sheila" uniqKey="Martins S" first="Sheila" last="Martins">Sheila Martins</name></region><name sortKey="Pontes Neto, Octavio M" sort="Pontes Neto, Octavio M" uniqKey="Pontes Neto O" first="Octavio M" last="Pontes-Neto">Octavio M. Pontes-Neto</name></country><country name="Colombie"><noRegion><name sortKey="Silva, Federico" sort="Silva, Federico" uniqKey="Silva F" first="Federico" last="Silva">Federico Silva</name></noRegion></country><country name="Inde"><noRegion><name sortKey="Pandian, Jeyaraj" sort="Pandian, Jeyaraj" uniqKey="Pandian J" first="Jeyaraj" last="Pandian">Jeyaraj Pandian</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Ricci, Stefano" sort="Ricci, Stefano" uniqKey="Ricci S" first="Stefano" last="Ricci">Stefano Ricci</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Stapf, Christian" sort="Stapf, Christian" uniqKey="Stapf C" first="Christian" last="Stapf">Christian Stapf</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Rationale, design, and progress of the ENhanced Control of Hypertension ANd Thrombolysis strokE stuDy (ENCHANTED) trial: An international multicenter 2 × 2 quasi-factorial randomized controlled trial of low- vs. standard-dose rt-PA and early intensive vs. guideline-recommended blood pressure lowering in patients with acute ischaemic stroke eligible for thrombolysis treatment.
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